Solutions Ĭobalt chloride is fairly soluble in water. The vapor pressure has been reported as 7.6 mmHg at the melting point. At about 706 ☌ (20 degrees below the melting point), the coordination is believed to change to tetrahedral. Properties Anhydrous Īt room temperature, anhydrous cobalt chloride has the cadmium chloride structure ( CdClĢ) (R 3m) in which the cobalt(II) ions are octahedrally coordinated. Commercial samples are usually the hexahydrate, which is one of the most commonly used cobalt salts in the lab. The anhydrous form is a blue crystalline solid the dihydrate is purple and the hexahydrate is pink. Claims of the formation of tri- and tetrahydrates have not been confirmed. The compound forms several hydrates CoClĢO, for n = 1, 2, 6, and 9. All rights reserved.Cobalt(II) chloride is an inorganic compound of cobalt and chlorine, with the formula CoClĢ. These data indicate that cobalt compounds are cytotoxic and genotoxic to human lung fibroblasts, and solubility plays a key role in cobalt-induced lung toxicity.Ĭobalt Cobalt chloride Cobalt oxide Cytotoxicity Genotoxicity.Ĭopyright © 2014 Elsevier Inc. Accordingly, we investigated the role of particle internalization in cobalt oxide-induced toxicity and found that particle-cell contact was necessary to induce cytotoxicity and genotoxicity after cobalt exposure. However, soluble cobalt induced cell cycle arrest indicated by the lack of metaphases at much lower intracellular cobalt concentrations compared to cobalt oxide. Based on intracellular cobalt ion levels, we found that soluble cobalt was more cytotoxic than particulate cobalt while particulate and soluble cobalt induced similar levels of genotoxicity. Exposure to both particulate and soluble cobalt induced a concentration-dependent increase in cytotoxicity, genotoxicity, and intracellular cobalt ion levels. Cobalt oxide and cobalt chloride were used as representative particulate and soluble cobalt compounds, respectively. Therefore, in this study, we sought to determine the cytotoxicity and genotoxicity of particulate and soluble cobalt in human lung cells. However, few studies have considered cobalt-induced toxicity in human lung cells. Cobalt is considered a possible human carcinogen with the lung being a primary target. Electronic address: exposure is increasing as cobalt demand rises worldwide due to its use in enhancing rechargeable battery efficiency, super-alloys, and magnetic products. Box 9300, Portland, ME 04101-9300, USA Department of Applied Medical Science, University of Southern Maine, 96 Falmouth St., P.O. Box 9300, Portland, ME 04101-9300, USA Maine Center for Environmental Toxicology and Health, University of Southern Maine, 96 Falmouth St., P.O.
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